It is so heart warming to receive such great news. This is one of the studies that GREYlong is supporting:
February 4, 2011
GREYlong
Dear Ms. Haberman-Wilson:
D07CA-034: MicroRNA Expression Profiling of Canine Osteosarcoma, William C. Kisseberth, DVM, PhD
UPDATE: Osteosarcoma, commonly known as bone cancer, is a significant cause of death in large and giant dog breeds. Because of the strong breed predilection for bone cancer, it is believed that genetic mutations predispose dogs to develop this disease.
To identify genetic causes of canine bone cancer, researchers at the Ohio State University have developed a customized genetic tool—canine microRNA microarray—which is being used to characterize microRNA expression in osteosarcoma cells.
The tool will also be used to determine any differences in microRNA expression between tumors and healthy tissue from Greyhounds and Rottweilers—two breeds with high risk of osteosarcoma.
To date, researchers have discovered 17 microRNAs that are differentially expressed in Greyhound and Rottweiler tumors, suggesting that breed-specific mechanisms may be involved in disease development and progression.
Based on these preliminary results, researchers are now evaluating a larger group of tumor and tissue samples, including those from Greyhounds, Rottweilers, Golden Retrievers and a mixed population of other breeds. Preliminary data from this larger group are encouraging in that researchers have identified 44 microRNAs that are expressed differently in different breeds. Notably, Golden Retrievers appear to have the most exceptional patterns of microRNA expression compared with other breeds.
Information gained from this study will identify microRNAs that may be important for determining diagnosis, prognosis and treatment of osteosarcoma in all dogs, but specifically for high-risk breeds.
In addition, this grant is serving as the research project for a PhD/veterinary medical oncology resident’s graduate thesis and as a Morris Animal Foundation veterinary student scholar project.